The Mateo Sanchez lab at the University of Cambridge is hiring two postdoctoral researchers to start as soon as possible after April 2023. The background of the candidates that we are looking for is the following (1) organic synthesis, organometallic chemistry, chemical biology and (2) molecular biology, protein engineering, directed evolution, yeast genetics, phage display. The positions are funded by the Wellcome Trust and the potential duration of the contracts are 4.5 and 6 years.
The Mateo Sanchez lab is a growing chemical-biology research group that aims to create new chemistry using biology, and understand biology by developing new molecular tools by applying chemistry principles. To achieve these goals, we leverage a wide range of techniques ranging from organic synthesis, chemical biology, optogenetics, protein engineering, directed evolution, yeast genetics to neuroscience.
Descripción de la oferta
Information about the positions offered and the project:
- Position in synthetic chemistry: We are looking for someone with a strong background in chemistry with an emphasis in chemical biology, organometallic chemistry, and catalysis. The researcher will synthetize new substrates to detect different enzymatic activities, which will be later employed in novel evolutionary campaigns for the evolution of enzymes. Another part of the project will consist of the discovery and development of new chemical reactions catalysed by evolved metallo-enzymes.
- Position in protein engineering / synthetic biology: We are looking for a biotechnologist or molecular biologist with a strong background in protein engineering and synthetic biology, ideally in directed evolution. The project will consist in implementing new platforms for directed evolution of enzymes like protases or photocleavable proteins. In addition, we are also interested in antibody engineering. The directed evolution will be carried out in different organisms like phage, bacteria or yeast. The evolved mutants will be incorporated in different molecular tools for cell biology, optogenetics, and neuroscience.
Presentación de solicitudes
To be fully considered, all applications should include a full CV including your publication list, a cover letter that highlights your research background, the research area you would be interested in working on, and finally, the names and contact details of two references. Please email me at misanche@ic.ac.uk Candidates will be firstly virtually interviewed, and successful applicants will be later invited to visit the lab. Candidates will be considered on a rolling basis until the position is filled.