Descripción de la oferta
The Solute Carrier family 26 (SLC26) includes functionally versatile anion transporters that are of pathophysiological relevance in the gastro-intestinal tract, kidney and lung. SLC26A11 stands out among the ten functional homologs present in humans because of the pH dependency of its chloride/sulfate exchange and the presence of a unique glutamate residue in the anion binding site, suggesting a novel proton-coupled transport mechanism.
Expected Results:
– Investigation of the molecular mechanism of proton transfer in SLC26A11
– Performing molecular dynamics simulations, both classical and quantum mechanics/molecular mechanics
– Employing enhanced sampling methods like metadynamics
– Analysis and interpretation of the results and design of further simulations
– Exchange with internal as well as external project partners, both national and international
– Preparing scientific publications and project reports and presentation at conferences
Perfil buscado
– University degree (Master) in Chemistry, Biochemistry, Biology, Physics or related fields
– Experience with UNIX-like operating systems
– Ideal prior knowledge on MD simulations and QM/MM
– Excellent knowledge of written and oral English: TOEFL or equivalent evidence of English-speaking skills
– Interactive person with good communication and organizational skills for exchange with colleagues and cooperation partners
Used to work in international and interdisciplinary teams
Presentación de solicitudes
Applications can be submitted through the button available at the bottom of this page:
https://www.fz-juelich.de/en/careers/jobs/2025D-016
