Ana Domingo Muelas

CIBER de Enfermedades Neurodegenerativas (CIBERNED). Instituto Biotecnología y Biomedicina. Facultad Ciencias Biológicas. Universidad de Valencia
Cónsul SEBBM (Valencia)

After obtaining a bachelor’s degree in Biochemistry and Biomedical Sciences in 2013 and a MSc degree in Research in Molecular, Cellular and Genetics Biology in 2014 at the University of Valencia, I started my doctoral studies at Prof. Isabel Fariñas lab (University of Valencia). I obtained a FPU predoctoral fellowhip from the Ministerio de Educación y Ciencia that also funded a 3-months stay at Robin Lovell-Badge lab at the Francis Crick Institute in London (United Kingdom) in 2017. In 2019, I obtained my international PhD degree with the highest qualification. Since I joined Prof. Fariñas lab as an undergraduate student my research interest has been the molecular regulation of adult neural stem cells (NSC) in their homeostatic microenvironment or niche. I have focused in identifying and delving into the molecular mechanisms that maintain stemness and intrinsic regulators that coordinate and orchestrate the transition between quiescent and actively proliferating cell states. Due to my expertise in NSC biology and molecular background I have also contributed to projects in collaboration with other labs in the field, which are undergoing review or have already been published as preprints (doi: 10.1101/2020.08.12.247627). I am now a researcher for the Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED).

Indicadores generales de calidad de la producción científica

  • Sum of times cited: 91 (without self-citations: 87)
  • Average citations/year: 15.17
  • Publications in the first quartile, Q1: 5
  • H-index: 4

Publicaciones

  1. Belenguer G*, Duart-Abadia P*, Domingo-Muelas A, Morante-Redolat JM and Fariñas I (2021). Cell population analysis of the adult murine subependymal neurogenic lineage by flow cytometry. STAR Protocols, 2(2):100425. doi: 10.1016/j.xpro.2021.100425. (*) Equal contribution.
  2. Belenguer G, Duart-Abadia P, Jordán-Pla A, Domingo-Muelas A, Blasco-Chamarro L, Ferrón SR, Morante-Redolat JM and Fariñas I (2021). Adult neural stem cells are alerted by systemic inflammation through TNF-α receptor signaling. Cell Stem Cell, S1934-5909(20)30510-5. IF: 20.860 (Q1). doi: 10.1016/J.STEM.2020.10.016.
  3. Muñoz-Soriano V, Domingo-Muelas A, Li T, Gamero E, Bizy A, Fariñas I, Alepuz P, Paricio N (2017). Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins. Scientific Reports, 7(1):9580. IF: 4,122 (Q1). doi: 10.1038/s41598-017-10057-y.
  4. Chirivella L(*), Kirstein M(*), Ferrón SR, Domingo-Muelas A, Durupt FC, Acosta- Umanzor C, Cano-Jaimez M, Pérez-Sánchez F, Barbacid M, Ortega S, Burks D, Fariñas I (2017). Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin-IRS2 signals. Stem Cells, 35(12):2403-2416. IF: 5.587 (Q1). doi: 10.1002/stem.2694. (*) Equal contribution.
  5. Belenguer G(*), Domingo-Muelas A(*), Ferrón SR, Morante-Redolat JM, Fariñas I (2016). Isolation, culture and analysis of adult subependymal neural stem cells. Differentiation, 91(4-5):28-41. IF: 2.567 (Q2). doi: 10.1016/j.diff.2016.01.005. (*) Equal contribution.
  6. Ferrón SR, Radford EJ(*), Domingo-Muelas A(*), Kleine I, Ramme A, Gray D, Sandovici I, Constancia M, Ward A, Menheniott TR, Ferguson-Smith AC (2015). Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis. Nature Communications, 6:8265. IF: 11.329 (Q1). doi:10.1038/ncomms9265. (*) Equal contribution.
  7. Montalbán-Loro R, Domingo-Muelas A, Bizy A, Ferrón SR (2015). Epigenetic regulation of stemness maintenance in the neurogenic niches. World Journal of Stem Cells, 7(4):700-10. IF: 4.376 (Q1). doi: 10.4252/wjsc.v7.i4.700.

Proyectos (equipo de trabajo, desde 2014)

  • 2018-2020. Regulación del comportamiento de las células madre neurales por el medio sistémico: el nicho extendido. MINECO (SAF2017-86690-R).
  • 2017-2021. Efectos directos y remotos de la respuesta inflamatoria sobre las células madre neurales. Generalitat Valenciana (PROMETEO/2017/030).
  • 2017-2020. RETIC de Terapia Celular. ISCIII (RD16/0011/0017).
  • 2015-2017. Regulación molecular de la quiescencia: células madre neurales. MINECO (SAF2014-54581-R).
  • 2014-2018. Estudio de células madre en el ámbito de las investigaciones básicas en terapia celular. Fundación Botín-Banco de Santander.
  • 2006-vigente (since 2014). CIBER de Enfermedades Neurodegenerativas (CIBERNED). ISCIII (CB06/05/0086).

Contratos

  • 2019-actualidad: Investigadora postdoctoral. CIBER de Enfermedades Neurodegenerativas (CIBERNED, ISCIII).
  • 2018-2019: Investigadora no-doctora. Universitat de València.
  • 2014-2018: Personal Investigador en Formación (becaria predoctoral FPU).Universitat de València.
Datos de contacto
963543246
Instituto Universitario de Biotecnología y Biomedicina
Calle Dr Moliner 50 - 46010 Valencia