Datos del evento
C/ Américo Vespucio 24, Edificio Cabimer, 41092 Seville (Spain)
Genome integrity relies on the high-fidelity of DNA replication, which continuously faces topological barriers, secondary DNA structures, DNA lesions, and obstacles such as transcription-replication conflicts. When replication forks stall, the cell activates the DNA damage response through a signal transduction cascade regulated by the checkpoint sensor kinases ATR and ATM. Checkpoint activation slows origin firing and stabilizes forks to prevent their collapse into double-strand breaks (DSBs). Should DSBs occur, the homologous recombination (HR) repair pathway primarily acts to allow proper replication resumption.
Understanding how these distinct cellular events physically and functionally interact is critical to deciphering the major mechanisms leading to genome instability—a hallmark of cancer and numerous genetic diseases.
The V Severo Ochoa Conference (CSO) will gather world-leading specialists and top national researchers to discuss current trends, recent breakthroughs, and the biomedical implications of genome integrity research.
Confirmed speakers:
- Matthias Altmeyer (University of Zurich (UZH), Zurich, CH)
- Rodrigo Bermejo (Centro de Investigaciones Biológicas (CIB), Madrid, ES)
- Petr Cejka (Institute for Research in Biomedicine (IRB), Bellinzona, CH)
- Vincenzo Costanzo (The FIRC Institute of Molecular Oncology (IFOM), Milan, IT)
- John Diffley (The Francis Crick Institute, London, UK)
- Cristina González-Aguilera (Centro Andaluz de BIologia Moluclar y Medicina Regenerativa (CABIMER), Sevilla, ES)
- Maite Huarte (CIMA Universidad de Navarra, Pamplona, ES)
- Juan Méndez (Centro Nacional de Investigaciones Biológicas (CNIO), Madrid, ES)
- Jo Morris (University of Birmingham, Brimingham, UK)
- Zuzanna Storchova (Rheinland-Pfälzische Technische Universität, Kaiserslautern, DE)
Organizers:
- Andrés Aguilera (Universidad de Sevilla – CABIMER)
- Belén Gómez (Universidad de Sevilla – CABIMER)
