Datos del evento
A Coruña (Spain)
Cellular aging and metabolism are deeply interconnected, shaping longevity, health, and disease. Cellular metabolism drives essential biochemical processes, while aging is characterized by a progressive decline in function and an increased risk of age-related diseases, including neurodegenerative disorders, cardiovascular disease, diabetes, and cancer.
A key player in this process is cellular senescence, a state of irreversible cell cycle arrest that promotes chronic inflammation and tissue dysfunction through the senescence-associated secretory phenotype (SASP). While senescence serves as a protective mechanism against uncontrolled cell growth, it paradoxically contributes to cancer and other diseases by fostering a pro-inflammatory and degenerative environment.
Metabolic disturbances, including oxidative stress, mitochondrial dysfunction, and DNA damage, accelerate senescence, impair cellular repair mechanisms, and drive the progression of age-related diseases. Additionally, stem cells, which are essential for tissue maintenance and regeneration, experience age-related decline due to metabolic shifts, reducing their ability to repair damage and contributing to both degenerative conditions and malignancies.
During this meeting, we will explore the intricate connections between metabolism, senescence, mitochondria, DNA stability, stem cell biology, cancer, and age-related diseases. By bringing together leading experts, this symposium aims to advance discussions on the latest strategies to modulate aging, enhance tissue regeneration, and develop innovative therapies to combat age-related diseases and cancer, ultimately promoting healthier aging and longevity.
